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NSC-697923(2-[(4-甲基苯基)磺酰]-5-硝基呋喃),作为一种高效的UBE2N(泛素结合酶E2 N,Ubc13)抑制剂,通过两种不同机制诱导神经母细胞瘤(NB)细胞的死亡。在p53野生型NB细胞中,NSC-697923促进p53的核内输入,从而触发细胞死亡。同时,在p53突变型NB细胞中,NSC-697923激活JNK介导的凋亡途径,导致细胞死亡。此外,NSC-697923还抑制DNA损伤和NF-κB信号传导,进一步增强其抗肿瘤活性。
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NSC-697923(2-[(4-甲基苯基)磺酰]-5-硝基呋喃),作为一种高效的UBE2N(泛素结合酶E2 N,Ubc13)抑制剂,通过两种不同机制诱导神经母细胞瘤(NB)细胞的死亡。在p53野生型NB细胞中,NSC-697923促进p53的核内输入,从而触发细胞死亡。同时,在p53突变型NB细胞中,NSC-697923激活JNK介导的凋亡途径,导致细胞死亡。此外,NSC-697923还抑制DNA损伤和NF-κB信号传导,进一步增强其抗肿瘤活性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 183 | 现货 | |
5 mg | ¥ 397 | 现货 | |
10 mg | ¥ 663 | 现货 | |
25 mg | ¥ 1,150 | 现货 | |
50 mg | ¥ 1,680 | 现货 | |
100 mg | ¥ 2,530 | 现货 | |
500 mg | ¥ 5,950 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 421 | 现货 |
产品描述 | NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct mechanisms. In p53 wild-type NB cells, NSC-697923 promotes the nuclear importation of p53, thereby triggering cell death. Meanwhile, in p53 mutant NB cells, NSC-697923 activates the JNK-mediated apoptotic pathway, leading to cell death. Additionally, NSC-697923 inhibits DNA damage and NF-κB signaling, further contributing to its antitumor activity. |
体外活性 | NSC697923(0-5 μM;24小时)对NB细胞系表现出细胞毒作用。同时,NSC697923(3μM;2小时)通过激活JNK介导的凋亡途径,可诱导p53突变型NB细胞的凋亡。此外,NSC697923通过促进p53核内转移和激活,在p53野生型NB细胞系中诱导凋亡[1]。 |
体内活性 | NSC697923(5 mg/kg;i.p.;每日一次,连续10天)在SH-SY5Y和NGP异种移植瘤模型中抑制NB肿瘤生长[1]。 |
别名 | 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran |
分子量 | 267.26 |
分子式 | C11H9NO5S |
CAS No. | 343351-67-7 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
溶解度信息 | Ethanol: 6.7 mg/mL (25 mM)), Heating is recommended. DMSO: 180 mg/mL (673.5 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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