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Lecimibide (DuP 128) 是一种有效且具有选择性的酰辅酶 A 胆固醇酰基转移酶(ACAT)抑制剂,可用于研究由于高脂带来的疾病。
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Lecimibide (DuP 128) 是一种有效且具有选择性的酰辅酶 A 胆固醇酰基转移酶(ACAT)抑制剂,可用于研究由于高脂带来的疾病。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 990 | 现货 | |
5 mg | ¥ 2,470 | 现货 | |
10 mg | ¥ 3,700 | 现货 | |
25 mg | ¥ 5,970 | 现货 | |
50 mg | ¥ 8,260 | 现货 | |
100 mg | ¥ 10,900 | 现货 | |
500 mg | ¥ 22,300 | 现货 |
产品描述 | Lecimibide (DuP 128) is a potent and selective inhibitor of acyl coenzyme A: cholesterol acyltransferase (ACAT), which can be used to study diseases due to high lipids. |
体外活性 | Lecimibide (DuP 128) (10 μM; 24 h) can inhibit 85% of the cellular esterification reaction in HepG2 cells.[1] |
体内活性 | Lecimibide (DuP 128) (2.2 mg/kg/day.; i.v) significantly reduced total plasma triglyceride and very low-density lipoprotein (VLDL) triglyceride concentrations in pigs fed high fat and cholesterol, respectively 36% and 31%. There were no significant effects on total cholesterol, VLDL cholesterol, LDL cholesterol, HDL cholesterol, or LDL apo B concentrations.[2] |
别名 | DuP128, DuP-128, DuP 128 |
分子量 | 590.77 |
分子式 | C34H40F2N4OS |
CAS No. | 130804-35-2 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 55 mg/mL (93.1 mM) | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
DMSO
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