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GSK2194069 是 一种具有活性的脂肪酸合成酶 (FASN) 的 β-酮基还原酶 (KR)特异性抑制剂,在检测释放的 CoA 的试验中测的 IC50 为7.7 nM。GSK2194069 通过作用于乙酰乙酰辅酶 A 和 NADPH 来抑制 FAS 的癌细胞增殖。
GSK2194069 是 一种具有活性的脂肪酸合成酶 (FASN) 的 β-酮基还原酶 (KR)特异性抑制剂,在检测释放的 CoA 的试验中测的 IC50 为7.7 nM。GSK2194069 通过作用于乙酰乙酰辅酶 A 和 NADPH 来抑制 FAS 的癌细胞增殖。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥ 1,099 | 现货 |
产品描述 | GSK2194069 is an active β-keto reductase (KR)-specific inhibitor of fatty acid synthase (FASN) with an IC50 of 7.7 nM in an assay for the detection of released CoA.GSK2194069 inhibits the proliferation of FAS in cancer cells through the action of acetoacetyl-coenzyme A and NADPH. |
靶点活性 | Phosphatidylcholine:15.5 ± 9 nM(EC50), β-ketoyl reductase:7.7 nM |
体外活性 | GSK2194069 (100 nM; 24 h) suppresses fatty acid synthase (FAS) activity in cancer cell lines (KATO-III, MKN45, A549, SNU-1) while maintaining FAS protein production levels.[1] GSK2194069 (5 μM and 20 μM) shows higher efficacy in FASN-positive LNCaP cells rather than FASN-negative PC3 cells, with the higher FASN Expression level in LNCaP cells.[2] GSK2194069 (50 μM; 24 h) inhibits the growth of LNCaP-LN3 human prostate cancer cells.[3] GSK2194069 (60.4 nM; 24 h) displays properties of metabolomics, including L-acetyl carnitine, stearoyl carnitine, vaccenyl carnitine, and palmitoyl-L-carnitine decrease in LNCaP-LN3 cells.[3] |
分子量 | 428.48 |
分子式 | C25H24N4O3 |
CAS No. | 1332331-08-4 |
存储 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 90.0 mg/mL (210.0 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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