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DL-Penicillamine (3-Sulfanylvaline) 是一种螯合剂,推荐用于去除威尔逊病患者体内多余的铜。 它仅存在于使用或服用该药物的个体中。它是青霉素类抗生素最具特征的降解产物。它被用作抗风湿药和威尔逊病的螯合剂。
DL-Penicillamine (3-Sulfanylvaline) 是一种螯合剂,推荐用于去除威尔逊病患者体内多余的铜。 它仅存在于使用或服用该药物的个体中。它是青霉素类抗生素最具特征的降解产物。它被用作抗风湿药和威尔逊病的螯合剂。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | ¥ 162 | 现货 | |
10 mg | ¥ 265 | 现货 | |
25 mg | ¥ 583 | 现货 | |
50 mg | ¥ 874 | 现货 | |
100 mg | ¥ 1,313 | 现货 | |
500 mg | ¥ 2,750 | 现货 |
产品描述 | DL-Penicillamine (3-Sulfanylvaline) is a chelating agent recommended for the removal of excess copper in patients with Wilson's disease. DL-Penicillamine is only found in individuals that have used or taken this drug. It is the most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease. From in vitro studies which indicate that one atom of copper combines with two molecules of DL-penicillamine. DL-Penicillamine also reduces excess cystine excretion in cystinuria. This is done, at least in part, by disulfide interchange between DL-penicillamine and cystine, resulting in the formation of penicillamine-cysteine disulfide, a substance that is much more soluble than cysteine and is excreted readily. DL-Penicillamine interferes with the formation of cross-links between tropocollagen molecules and cleaves them when newly formed. The mechanism of action of DL-penicillamine in rheumatoid arthritis is unknown although it appears to suppress disease activity. Unlike cytotoxic immunosuppressants, DL-penicillamine markedly lowers IgM rheumatoid factor but produces no significant depression in absolute levels of serum immunoglobulins. Also unlike cytotoxic immunosuppressants which act on both, DL-penicillamine in vitro depresses T-cell activity but not B-cell activity. |
别名 | DL-青霉胺, 3-Sulfanylvaline |
分子量 | 149.21 |
分子式 | C5H11NO2S |
CAS No. | 52-66-4 |
Smiles | CC(C)(S)C(N)C(O)=O |
密度 | 1.204g/cm3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
溶解度信息 | H2O: 5 mM DMSO: Insoluble | |||||||||||||||
溶液配制表 | ||||||||||||||||
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