DS-1040 Tosylate

Name: DS-1040 Tosylate
Brand: TargetMol
SKU: T11100
Price: 1210 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T11100Cas号 1335138-89-0

DS-1040 Tosylate is an oral active, selective thrombolytic inhibitor with IC50s of 5.92 nM and 8.01 nM for human and rat TAFIa, is an orally active, selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC50s of 5.92 nM and 8.01 nM for human and rat TAFIa. DS-1040 Tosylate is a fibrinolysis enhancer for thromboembolic diseases[1].

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DS-1040 Tosylate

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产品编号 T11100Cas号 1335138-89-0

规格	价格	库存
2 mg	¥ 945	5日内发货
5 mg	¥ 1,580	5日内发货
25 mg	¥ 6,150	8-10周
50 mg	¥ 7,990	8-10周
100 mg	¥ 13,700	8-10周
1 mL x 10 mM (in DMSO)	¥ 1,810	5日内发货

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TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

产品介绍

生物活性

产品描述	DS-1040 Tosylate is an oral active, selective thrombolytic inhibitor with IC50s of 5.92 nM and 8.01 nM for human and rat TAFIa, is an orally active, selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC50s of 5.92 nM and 8.01 nM for human and rat TAFIa. DS-1040 Tosylate is a fibrinolysis enhancer for thromboembolic diseases[1].
靶点活性	TAFIa (human):5.92 nM , TAFIa (rat):8.01 nM
体外活性	Ds-1040 Tosylate inhibited human carboxypeptidase N (CPN) in vitro with an IC50 of 3.02 mM.
体内活性	DS-1040 Tosylate (0.0005-0.5 mg/kg; IV) significantly reduces the microthrombi index at doses of 0.005 mg/kg and greater. DS1040 (0.016, 0.031, 0.063, 0.13, 0.25, 0.50 mg/kg; i.v.) increases plasma D-dimer levels in a dose-dependent manner in the microthrombosis model. ED50 and EDmax are 122 and 221 nmol/L, respectively. DS-1040 (0.25, 0.5, 1, 2, 4, 8, 16 mg/kg; orally) also increases plasma D-dimer levels. EC50 and ECmax values are 114 and 231 nmol/L, respectively.

化学信息

分子量	465.61
分子式	C₂₃H₃₅N₃O₅S
CAS No.	1335138-89-0
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

H2O: 100 mg/mL (214.77 mM), Sonication is recommended.

溶液配制表

	1mg	5mg	10mg	50mg
1 mM	2.1477 mL	10.7386 mL	21.4772 mL	107.3860 mL
5 mM	0.4295 mL	2.1477 mL	4.2954 mL	21.4772 mL
10 mM	0.2148 mL	1.0739 mL	2.1477 mL	10.7386 mL
20 mM	0.1074 mL	0.5369 mL	1.0739 mL	5.3693 mL
50 mM	0.0430 mL	0.2148 mL	0.4295 mL	2.1477 mL
100 mM	0.0215 mL	0.1074 mL	0.2148 mL	1.0739 mL