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N-Acetyl-5-hydroxytryptamine (O-Demethylmelatonin) 是褪黑激素的直接前体,能够有效激活TrkB 受体。
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N-Acetyl-5-hydroxytryptamine (O-Demethylmelatonin) 是褪黑激素的直接前体,能够有效激活TrkB 受体。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | ¥ 297 | 现货 | |
50 mg | ¥ 793 | 现货 | |
100 mg | ¥ 1,352 | 现货 | |
200 mg | ¥ 2,329 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 233 | 现货 |
产品描述 | N-Acetyl-5-hydroxytryptamine (O-Demethylmelatonin) , also known as Normelatonin, is the immediate precursor of melatonin. It is produced from serotonin by the enzyme aralkylamine N-acetyltransferase and is converted to melatonin by acetylserotonin O-methyltransferase. It can potently activate TrkB receptor. |
体外活性 | N-Acetyl-5-hydroxytryptamine 以昼夜节律方式激活TrkB受体。N-Acetyl-5-hydroxytryptamine迅速且昼夜节律地激活TrkB,并以TrkB依赖的方式呈现抗抑郁效应。N-Acetyl-5-hydroxytryptamine能快速激活TrkB,但不激活TrkA或TrkC,并且这一过程不依赖神经营养因子和MT3受体[1]。 |
体内活性 | 为探究N-Acetyl-5-hydroxytryptamine是否能够在体内触发TrkB激活,本研究使用了TrkB F616A基因敲入小鼠。研究发现,TrkB F616A的激活可以被1NMPP1(一种来源于激酶抑制剂PP1的衍生物)特异性阻断,从而导致TrkB零表型。为评估N-Acetyl-5-hydroxytryptamine是否能模仿BDNF的作用,制备了来自TrkB F616A基因敲入小鼠的皮层神经元。结果与先前报告一致,BDNF和NAS介导的TrkB磷酸化被1NMPP1选择性降低,而K252a无影响;同时,5-羟色胺或褪黑素对此无效。这些发现表明,NAS强烈诱导了野生型TrkB和TrkB F616A酪氨酸的磷酸化及激活[1]。 |
别名 | O-Demethylmelatonin, N-乙酰-5-羟色胺, Normelatonin, N-Acetylserotonin |
分子量 | 218.25 |
分子式 | C12H14N2O2 |
CAS No. | 1210-83-9 |
Smiles | CC(=O)NCCc1c[nH]c2ccc(O)cc12 |
密度 | 1.268 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 50 mg/mL (229.1 mM) Ethanol: 10 mg/mL | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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