Gefarnate is a synthetic compound used for the treatment of gastric ulcers,and also used in the treatment of dry eye syndrome.

Gefarnate在剂量依赖性的方式中刺激结膜组织分泌黏蛋白样糖蛋白。在兔子干眼模型中，向眼睛施用Gefarnate软膏导致角膜中rose bengal的渗透性以剂量依赖性下降，当浓度≥0.3%时效果显著。在猫干眼模型中，施用Gefarnate软膏后角膜荧光素染色得分显著下降[1]。

Conjunctival tissue isolated from rabbits was treated with gefarnate. Mucin-like glycoprotein was detected in the culture supernatant by an enzyme-linked lectin assay. Gefarnate ointment was topically applied to eyes once daily for 7 days in the rabbit dry-eye model, in which the lacrimal glands, Harderian gland, and nictitating membrane were removed, or for 4 weeks in the cat dry-eye model, in which the lacrimal gland and nictitating membrane were removed. Corneal epithelial damage was evaluated by measurement of corneal permeability by rose bengal in the rabbit model or by fluorescein staining in the cat model[1].