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Azido-PEG6-alcohol is a polyethylene glycol (PEG)-based PROTAC linker utilized in PROTAC synthesis[1]. It also functions as a non-cleavable PEG linker consisting of six units, specifically employed in the synthesis of antibody-drug conjugates (ADCs)[2].
Azido-PEG6-alcohol is a polyethylene glycol (PEG)-based PROTAC linker utilized in PROTAC synthesis[1]. It also functions as a non-cleavable PEG linker consisting of six units, specifically employed in the synthesis of antibody-drug conjugates (ADCs)[2].
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | ¥ 122 | 期货 | |
10 mg | ¥ 158 | 期货 |
产品描述 | Azido-PEG6-alcohol is a polyethylene glycol (PEG)-based PROTAC linker utilized in PROTAC synthesis[1]. It also functions as a non-cleavable PEG linker consisting of six units, specifically employed in the synthesis of antibody-drug conjugates (ADCs)[2]. |
体外活性 | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
分子量 | 307.34 |
分子式 | C12H25N3O6 |
CAS No. | 86770-69-6 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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