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Paprotrain ((alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile) 是可渗透细胞的 kinesin MKLP-2的抑制剂,抑制 MKLP-2 的 ATPase 活性,IC50值为 1.35 μM,Ki 值为 3.36 μM。它对 DYRK1A 有中等的抑制作用,IC50值为 5.5 μM。
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Paprotrain ((alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile) 是可渗透细胞的 kinesin MKLP-2的抑制剂,抑制 MKLP-2 的 ATPase 活性,IC50值为 1.35 μM,Ki 值为 3.36 μM。它对 DYRK1A 有中等的抑制作用,IC50值为 5.5 μM。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 186 | 现货 | |
5 mg | ¥ 413 | 现货 | |
10 mg | ¥ 579 | 现货 | |
25 mg | ¥ 993 | 现货 | |
50 mg | ¥ 1,730 | 现货 | |
100 mg | ¥ 2,650 | 现货 | |
200 mg | ¥ 3,880 | 现货 | |
500 mg | ¥ 6,150 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 433 | 现货 |
产品描述 | Paprotrain ((alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile) inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM. |
靶点活性 | MKLP2:1.35 μM, MKLP2:3.36 Μm(Ki) |
体外活性 | Paprotrain-treated porcine oocytes suffer failure of nuclear maturation.?The number of oocytes arrested at early MI stage increase in a dose-dependent manner after KIF20A activity inhibition, while the percentage of oocytes that reach ATI and MII stages decrease after treatment[3]. |
别名 | (alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile |
分子量 | 245.28 |
分子式 | C16H11N3 |
CAS No. | 57046-73-8 |
Smiles | N#C\C(=C/c1cccnc1)c1c[nH]c2ccccc12 |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 100 mg/mL (407.70 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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