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Alvimopan (LY 246736) 是一种选择性和竞争性 μ 阿片受体拮抗剂,IC50值为 1.7 nM。它存在于肌间和黏膜下神经元以及人体肠道固有层的免疫细胞中,可用于术后肠梗阻的研究。
Alvimopan (LY 246736) 是一种选择性和竞争性 μ 阿片受体拮抗剂,IC50值为 1.7 nM。它存在于肌间和黏膜下神经元以及人体肠道固有层的免疫细胞中,可用于术后肠梗阻的研究。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 333 | 现货 | |
2 mg | ¥ 482 | 现货 | |
5 mg | ¥ 796 | 现货 | |
10 mg | ¥ 1,250 | 现货 | |
25 mg | ¥ 2,520 | 现货 | |
50 mg | ¥ 3,690 | 现货 | |
100 mg | ¥ 5,290 | 现货 | |
500 mg | ¥ 10,700 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 877 | 现货 |
产品描述 | Alvimopan (LY 246736) is a synthetic trans-3, 4-dimethyl-4-(3-hydroxyphenyl) piperidine with peripherally selective opioid mu receptor antagonist activity. Alvimopan is a selective and competitive antagonist at mu-opioid receptors, found in myenteric and submucosal neurons and the immune cells of the lamina propria in the human gut. Upon administration, this agent binds to mu-opioid receptors in the gut, thereby reversing opioid-related disturbances in gut motility. Alvimopan is approximately three to nine times more potent than naloxone. |
靶点活性 | μ opioid receptor:0.77 nM(Ki), κ opioid receptor:40 nM(Ki), δ opioid receptor:4.4 nM, δ opioid receptor:4.4 nM(Ki) |
别名 | 爱维莫潘 |
分子量 | 424.53 |
分子式 | C25H32N2O4 |
CAS No. | 156053-89-3 |
Smiles | C[C@H]1CN(C[C@H](Cc2ccccc2)C(=O)NCC(O)=O)CC[C@@]1(C)c1cccc(O)c1 |
密度 | 1.166g/cm3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 80 mg/mL (188.4 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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