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Namitecan
还可以产品编号 T16268Cas号 372105-27-6
别名 ST-1968
Namitecan is an effective inhibitor of topoisomerase I. It has antitumor property.
Namitecan
还可以产品编号 T16268 别名 ST-1968Cas号 372105-27-6
Namitecan is an effective inhibitor of topoisomerase I. It has antitumor property.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 2 mg | ¥ 2,940 | 5日内发货 | |
| 25 mg | ¥ 14,500 | 10-14周 | |
| 50 mg | ¥ 18,900 | 10-14周 | |
| 100 mg | ¥ 29,500 | 10-14周 |
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产品介绍
生物活性
化学信息
| 产品描述 | Namitecan is an effective inhibitor of topoisomerase I. It has antitumor property. |
| 体外活性 | Namitecan decreases a dose-dependent decrease in EGFR expression in the different cell lines[1]. Namitecan and cetuximab cooperate in inhibiting EGFR expression. ST1968 causes a comparable level of apoptosis in A431 and A431/TPT cells (IC50: 0.21 and 0.29 μM)[2]. |
| 体内活性 | Namitecan (10 mg/kg) in combination with cetuximab (1 mg/mouse) induces synergistic antitumor effects in SCC models as a function of EGFR gene copy number[1]. ST1968 (25 mg/kg) causes acceptable body weight loss and no toxic deaths. ST1968 produces a 100% complete response rate in the mice bearing the A431 tumor and retains a relevant activity in the topotecan-resistant tumor[2]. |
| 别名 | ST-1968 |
| 分子量 | 434.44 |
| 分子式 | C23H22N4O5 |
| CAS No. | 372105-27-6 |
| 密度 | 1.51 g/cm3 (Predicted) |
储存&溶解度
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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