TD-0212 TFA

Name: TD-0212 TFA
Brand: TargetMol
SKU: T13125L
Rating: 4.5 (1 reviews)

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产品编号 T13125LCas号 1073549-11-7

TD-0212 TFA is an orally active dual pharmacology antagonist of angiotensin II type 1 receptor (AT1) and inhibitor of neprilysin (NEP)(pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP).

TD-0212 TFA

还可以

产品编号 T13125LCas号 1073549-11-7

TD-0212 TFA is an orally active dual pharmacology antagonist of angiotensin II type 1 receptor (AT1) and inhibitor of neprilysin (NEP)(pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP).

规格	价格	库存
25 mg	¥ 19,400	10-14周
50 mg	¥ 25,800	10-14周
100 mg	¥ 33,500	10-14周

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产品介绍

生物活性

产品描述	TD-0212 TFA is an orally active dual pharmacology antagonist of angiotensin II type 1 receptor (AT1) and inhibitor of neprilysin (NEP)(pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP).
靶点活性	NEP:9.2(pIC50), AT1:(pKi)8.9
体外活性	TD-0212 provides the enhanced activity of dual AT1/NEP inhibition and may have a lower risk of angioedema than dual ACE/NEP inhibition.
体内活性	In renin-dependent and non-dependent hypertension models, TD-0212 can lower blood pressure, similar to omapatrilat and the combination of AT1 receptor antagonist and NEP inhibitor.

化学信息

分子量	641.67
分子式	C₃₀H₃₅F₄N₃O₆S
CAS No.	1073549-11-7
密度	1.31g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 125 mg/mL (194.80 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5584 mL	7.7922 mL	15.5843 mL	77.9217 mL
5 mM	0.3117 mL	1.5584 mL	3.1169 mL	15.5843 mL
10 mM	0.1558 mL	0.7792 mL	1.5584 mL	7.7922 mL
20 mM	0.0779 mL	0.3896 mL	0.7792 mL	3.8961 mL
50 mM	0.0312 mL	0.1558 mL	0.3117 mL	1.5584 mL
100 mM	0.0156 mL	0.0779 mL	0.1558 mL	0.7792 mL