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BPH-1358 (NSC-50460) 是一种人 FPPS 和 UPPS 抑制剂,IC50值分别为 1.8 μM 和 110 nM,对金黄色葡萄球菌的 MIC 值大约为 250 ng/mL。
BPH-1358 (NSC-50460) 是一种人 FPPS 和 UPPS 抑制剂,IC50值分别为 1.8 μM 和 110 nM,对金黄色葡萄球菌的 MIC 值大约为 250 ng/mL。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 535 | 现货 | |
5 mg | ¥ 1,330 | 现货 | |
10 mg | ¥ 2,130 | 现货 | |
25 mg | ¥ 3,670 | 现货 | |
50 mg | ¥ 4,950 | 现货 | |
100 mg | ¥ 6,530 | 现货 | |
200 mg | ¥ 8,790 | 现货 |
产品描述 | BPH-1358 (NSC-50460) (NSC-50460) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor. With IC50s of 1.8 μM and 110 nM, respectively. And it is active against S. aureus in vitro (MIC ~250 ng/mL)[1][2]. |
靶点活性 | Bisphosphonate farnesyl diphosphate synthase (human):1.8 μM |
体外活性 | BPH-1358 against E. coli and S. aureus with EC50 of 300 nM and 290 nM, respectively[1]. BPH-1358 is the most potent inhibitor of both E. coli UPPS (EcUPPS) as well as S. aureus UPPS (SaUPPS), with an IC50 of 110 nM. |
体内活性 | BPH-1358 is active against S. aureus in vivo (20/20 mice survived an intraperitoneal infection model of MRSA strain)[1]. |
别名 | NSC50460 |
分子量 | 601.53 |
分子式 | C32H30Cl2N6O2 |
CAS No. | 5352-53-4 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度信息 | DMSO: Slightly soluble |
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