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5-Hydroxy-1-methylhydantoin (HD-003) 是一种可能用于治疗肾衰竭的抗氧化剂。它是肌酐代谢物,是一种羟基自由基清除剂,此前已显示通过抑制大鼠慢性肾病的进展来提供肾脏保护。 它是一种新型抗氧化药物,可完全抑制 B2-激肽受体(B2KR) 对 VSMC 中高葡萄糖 (25 mM) 刺激的反应,并且还显示可减弱 BK 对 VSMC 重塑的影响。它抑制 BK 诱导的 MAPK 磷酸化增加并减弱 VSMC 中结缔组织生长因子 (CTGF) 蛋白水平的增加。这些研究结果表明,它可能通过其抗氧化特性赋予血管保护免受高葡萄糖浓度和 BK 刺激以改善血管损伤和重塑。
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5-Hydroxy-1-methylhydantoin (HD-003) 是一种可能用于治疗肾衰竭的抗氧化剂。它是肌酐代谢物,是一种羟基自由基清除剂,此前已显示通过抑制大鼠慢性肾病的进展来提供肾脏保护。 它是一种新型抗氧化药物,可完全抑制 B2-激肽受体(B2KR) 对 VSMC 中高葡萄糖 (25 mM) 刺激的反应,并且还显示可减弱 BK 对 VSMC 重塑的影响。它抑制 BK 诱导的 MAPK 磷酸化增加并减弱 VSMC 中结缔组织生长因子 (CTGF) 蛋白水平的增加。这些研究结果表明,它可能通过其抗氧化特性赋予血管保护免受高葡萄糖浓度和 BK 刺激以改善血管损伤和重塑。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 218 | 现货 | |
5 mg | ¥ 496 | 现货 | |
10 mg | ¥ 787 | 现货 | |
25 mg | ¥ 1,570 | 现货 | |
50 mg | ¥ 2,480 | 现货 | |
100 mg | ¥ 3,730 | 现货 | |
200 mg | ¥ 5,320 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 418 | 现货 |
产品描述 | 5-Hydroxy-1-methylhydantoin (HD-003) is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, 5-Hydroxy-1-methylhydantoin , a hydroxyl radical scavenger, has previously been shown to confer renoprotection by inhibiting the progression of chronic kidney disease in rats. 5-Hydroxy-1-methylhydantoin is a novel anti-oxidant drug completely suppressed the expression of B2-kinin receptors (B2KR) in response to high glucose (25 mM) stimulation in VSMC and was also shown to attenuate the effects of BK on VSMC remodeling. 5-Hydroxy-1-methylhydantoin inhibited the BK-induced increase in MAPK phosphorylation and attenuated the increase in connective tissue growth factor (CTGF) protein levels in VSMC. These findings suggest that 5-Hydroxy-1-methylhydantoin may confer vascular protection against high glucose concentrations and BK-stimulation to ameliorate vascular injury and remodeling through its anti-oxidant properties. |
别名 | NZ-419, NZ419, NZ 419, HD-003, HD003, HD 003, 5-羟基-1-甲基咪唑啉-2,4-二酮 |
分子量 | 130.1 |
分子式 | C4H6N2O3 |
CAS No. | 84210-26-4 |
Smiles | OC1N(C)C(=O)NC1=O |
密度 | 1.516g/cm3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 60 mg/ml (525.85 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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