TRV056

Name: TRV056
Brand: TargetMol
SKU: T40920
Rating: 4.5 (1 reviews)

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产品编号 T40920Cas号 812644-79-4

别名 TRV056

TRV056 is a Gq-biased agonist of the angiotensin II type 1 receptor (AT1R), demonstrating efficacy in stimulating Gq-mediated cellular signaling. It can serve as a foundation for the development of Gq-biased AT1R agonists.

TRV056

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产品编号 T40920 别名 TRV056Cas号 812644-79-4

规格	价格	库存	数量
5 mg	¥ 1,160	6-8周

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产品描述	TRV056 is a Gq-biased agonist of the angiotensin II type 1 receptor (AT1R), demonstrating efficacy in stimulating Gq-mediated cellular signaling. It can serve as a foundation for the development of Gq-biased AT1R agonists.
体外活性	TRV056 is a “gain-of-function” ligand that have >10-fold greater allosteric coupling to Gq than AngII and is also more efficacious in stimulating cellular Gq-mediated signaling (e.g., IP1 generation). Compared to the endogenous ligand angiotensin II (AngII), “Gq-biased” AT1R agonists are more efficacious in stimulating Gq-mediated cellular signaling and in allosterically promoting Gq coupling[1].
别名	TRV056