Triphala is an Ayurvedic polyherbal formulation. Triphala inhibits NF-κB activation. Triphala exerts antifungal action, and with anti-adipogenic, anti-inflammatory, and antineoplastic activities.

In 3T3-L1 cell line, Triphala regulates adipogenesis through modulation of expression of adipogenic genes.In 3T3-L1 cells, Triphala significantly decreases the adipogenesis by reducing lipid accumulation and inhibiting the expression of adipogenic genes. The 3T3-L1 cells treated with Triphala show ~1.43-, 1.67-, and 2.5-fold decreases in lipid content at 1, 10, and 100 μg/mL concentrations, respectively, compared to the cells treated with induction cocktail alone. Triphala regulates lipid accumulation by down regulating expression of adipogenic genes, resulting into prevention of adipogenesis[1]. Triphala reduces expression of inflammatory mediators such as IL-17, COX-2, and RANKL through inhibition of NF-κB activation[2]. Triphala exerts antifungal action against Asperigillus species and has been reported to inhibit the fungus by up to 37.96% in vitro[2].