Teduglutide acetate, a GLP-2 analogue, maximizes small intestinal mucosal hypertrophy. Teduglutide acetate partially restores small intestinal epithelial function through an altered distribution of claudin-10, facilitating sodium recirculation for Na-coupled glucose transport and water absorption.

Teduglutide acetate 在 Nod2 k.o. 小鼠中降低了肠功能衰竭的发生率。在 wt 小鼠中，Teduglutide acetate 通过减少体重损失、降低血浆Dicirenone 浓度、降低粪便水分含量和减少粪便钠损失来减轻肠功能不全。Teduglutide acetate 治疗与增强的上皮细胞旁通道功能和紧密连接中claudin-10表达的增强有关，在绒毛尖部，它与钠-葡萄糖共同转运蛋白1（SGLT-1）共定位，后者介导钠耦合葡萄糖运输[1]。