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SPOP-IN-6b hydrochloride is a highly effective inhibitor of speckle-type POZ protein (SPOP), exhibiting an IC50 value of 3.58 μM.
SPOP-IN-6b hydrochloride is a highly effective inhibitor of speckle-type POZ protein (SPOP), exhibiting an IC50 value of 3.58 μM.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 mg | ¥ 10,600 | 1-2周 |
产品描述 | SPOP-IN-6b hydrochloride is a highly effective inhibitor of speckle-type POZ protein (SPOP), exhibiting an IC50 value of 3.58 μM. |
体外活性 | SPOP-IN-6b shows IC 50 s of 2-10.2 μM for A498, Caki-2, Ketr-3, 769-P, 0S-RC-2 and 786-0 cells[1]. SPOP-IN-6b (0.1-3.0 μM; 10 hours) can suppress SPOP activity, and then increase suppression cancer substrate protein PTEN and DUSP7 content[1]. |
体内活性 | SPOP-IN-6b (40-80 mg/kg; intraperitoneal injection; daily; for 25 days; nude mice) can slow down the growth of tumour by suppressing SPOP[1]. |
分子量 | 537.06 |
分子式 | C28H33ClN6O3 |
CAS No. | 2136270-68-1 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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