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Siomycin A is a thiopeptide antibiotic that selectively inhibits Forkhead box M1 (FOXM1) without affecting other Forkhead box family members, exhibiting anti-tumor properties and promoting apoptosis.
Siomycin A is a thiopeptide antibiotic that selectively inhibits Forkhead box M1 (FOXM1) without affecting other Forkhead box family members, exhibiting anti-tumor properties and promoting apoptosis.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
500 μg | ¥ 6,930 | 35日内发货 |
产品描述 | Siomycin A is a thiopeptide antibiotic that selectively inhibits Forkhead box M1 (FOXM1) without affecting other Forkhead box family members, exhibiting anti-tumor properties and promoting apoptosis. |
体外活性 | cell viability in a dose-dependent and a time-dependent association in K562, MCF7 and MiaPaCa-2 cells markedly reduced by Siomycin A (0-10 μM; 24-72 hours; K562, MCF7 and MiaPaCa-2 cells). Among the three cell lines(IC50 of the human leukemia K562 cells is the lowest at 6.25 μM at 24 h), while that for the human pancreatic cancer MiaPaCa-2 cells is 6.38 μM. However, the IC50 of the human pancreatic cancer MiaPaCa-2 cells at 48 and 72 h are the lowest of the three cell lines, which are 0.76 and 0.54 μM, respectively[1]. Siomycin A (0-10 μM; MiaPaCa-2 cells) treatment has potent proapoptotic effect in MiaPaCa-2 cells[1]. Siomycin A (0-10 μM; 24 hours; MiaPaCa-2 cells) treatment significantly reduces the expression levels of MMP-2, MMP-9 and α-tubulin protein in the MiaPaCa-2 cells[1]. |
体内活性 | In vivo mouse model,Siomycin A (1 μM; subcutaneous injection; for 4 weeks; male Balb/c nude mice) pretreatment decreases tumour growth [2]. |
别名 | 盐霉素 A |
分子量 | 1648.84 |
分子式 | C71H81N19O18S5 |
CAS No. | 12656-09-6 |
密度 | 1.65 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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