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L524-0366
很棒产品编号 T8570Cas号 951612-19-4
别名 [1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone
L524-0366 ([1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone) 是一种 TWEAK-Fn14 信号级联抑制剂。
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L524-0366
很棒 纯度: 98.60%
产品编号 T8570 别名 [1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanoneCas号 951612-19-4
L524-0366 ([1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone) 是一种 TWEAK-Fn14 信号级联抑制剂。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 mg | ¥ 1,297 | 现货 | |
| 2 mg | ¥ 1,939 | 现货 | |
| 5 mg | ¥ 2,927 | 现货 | |
| 10 mg | ¥ 4,388 | 现货 | |
| 25 mg | ¥ 7,320 | 现货 | |
| 50 mg | ¥ 9,870 | 现货 | |
| 100 mg | ¥ 13,300 | 现货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 2,770 | 现货 |
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纯度:98.60%
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TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。产品介绍
生物活性
化学信息
| 产品描述 | L524-0366 ([1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone) is a TWEAK-Fn14 signaling cascade inhibitor. |
| 体外活性 | L524-0366通过TAC减轻了不良重塑。TWEAK通过部分激活非典型NF-κB信号传导，诱导了来自WT但不是Fn14-/-纤维细胞的促炎症趋化因子，单核细胞趋化蛋白1的分泌。最终，在TAC后的小鼠以及人类衰竭心脏中，发现Fn14表达增加。 |
| 细胞实验 | Wild type (WT) and Fn14 knock out (Fn14-/-) mice were subjected to pressure overload [transaortic constriction (TAC)] for 1 or 6 weeks. A subset of WT TAC animals were treated with the Fn14 antagonist L524-0366. Cardiac function was measured by echocardiography. Cardiac fibrosis and macrophage infiltration were quantified using immunohistochemistry and flow cytometry, respectively. Cardiac fibroblasts were isolated for quantifying TWEAK-induced chemokine release. |
| 别名 | [1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone |
| 分子量 | 308.79 |
| 分子式 | C13H13ClN4OS |
| CAS No. | 951612-19-4 |
| Smiles | C(=O)(C1=CN(N=N1)C2=CC(Cl)=CC=C2)N3CCSCC3 |
| 密度 | no data available |
储存&溶解度
| 存储 | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| 溶解度信息 | 5% DMSO+95% Corn oil: 1 mg/mL (3.24 mM), In vivo: Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.  DMSO: 25 mg/ml (80.96 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
5% DMSO+95% Corn oil/DMSO
DMSO
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计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
剂量转换
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