购物车
- 全部删除
- 您的购物车当前为空
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥ 598 | 5日内发货 | |
5 mg | ¥ 987 | 6-8周 | |
10 mg | ¥ 1,550 | 6-8周 | |
100 mg | ¥ 6,990 | 6-8周 |
产品描述 | Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) has the potential in the type 1 diabetes mellitus research that is a potent inhibitor of 12/15-Lipoxygenases (LO) [1]. |
体外活性 | High glucose or 12(S)-HETE remarkably increased transendothelial dextran transport, and in combination it was increased further. Addition of the 12/15-LO inhibitor, CDC, partially suppressed dextran transport [1]. |
体内活性 | The high glucose and 12(S)-hydroxyeicosatetraenoic acid (HETE) could alter vascular endothelial (VE)-cadherin and β‐catenin phosphorylation levels, but did not alter total protein expression. However, the 12/15-LO inhibitor, Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC), antagonized the effect of high glucose on protein phosphorylation to mitigate destruction of the endothelial cell barrier, and the mouse diabetes mellitus model further confirmed these conclusions [1]. |
分子量 | 321.33 |
分子式 | C19H15NO4 |
CAS No. | 132465-11-3 |
存储 | Shipping with blue ice. |