ANG1005 is a brain-penetrating peptide-agent conjugate comprising a taxane derivative that features three paclitaxel molecules covalently bonded to Angiopep-2. This design facilitates crossing of the blood-brain and blood-cerebrospinal barriers, with subsequent penetration of malignant cells through the low-density lipoprotein receptor-related protein (LRP1) transport system [1] [2] [3].

ANG1005在增进脑部传递及治疗乳腺癌脑转移方面，比起游离紫杉醇表现出明显的优势[1]。