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Chalcone

产品编号 T2S0961Cas号 94-41-7
别名 benzylideneacetophenone, phenyl styryl ketone, Cinnamophenone, 查耳酮, benzalacetophenone, β-phenylacrylophenone

Chalcone (Cinnamophenone) 是从甘草中分离得到的一种芳香酮,可合成查耳酮衍生物。它具有多种生物和药理的活性,如抗炎、抗菌、抗癌、抗氧化、抗寄生虫等活性。

Chalcone

Chalcone

纯度: 97.27%
产品编号 T2S0961 别名 benzylideneacetophenone, phenyl styryl ketone, Cinnamophenone, 查耳酮, benzalacetophenone, β-phenylacrylophenoneCas号 94-41-7

Chalcone (Cinnamophenone) 是从甘草中分离得到的一种芳香酮,可合成查耳酮衍生物。它具有多种生物和药理的活性,如抗炎、抗菌、抗癌、抗氧化、抗寄生虫等活性。

规格价格库存数量
100 mg¥ 129现货
500 mg¥ 273现货
1 g¥ 389现货
5 g¥ 939现货
10 g¥ 1,390现货
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纯度:97.27%
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产品介绍

生物活性
产品描述
Chalcone (Cinnamophenone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.
靶点活性
EGFR:10 µM (in A431 cells)
体外活性
AG99,一种EGFR的强效抑制剂,被证明在一定程度上抑制了pp145的表达。AG99通过激活体外中的类半胱天冬酶蛋白酶促进正常细胞和癌细胞的死亡[2]。
细胞实验
Human bladder carcinoma cell line 5637 was maintained in RPMI1640 medium supplemented with 10% fetal calf serum (FCS), 1 mM L-glutamine, and antibiotics. Cells were grown at 37°C in a humidified 5% CO2 atmosphere. For all experiments, confluent cells were trypsinized, and aliquots of single-cell suspension were re-seeded at 0.5×10^6 cells/dish (100-mm diameter) or 0.1×106 cells/dish (60-mm diameter) and cultured in poly-L-lysine-coated new culture dishes containing normal culture media for 24-48 hours. After the normal growth treatment, cells were treated under several different conditions as specified in the text. When cell number and cell viability were determined, both attached cells and unattached cells were collected by trypsinization and sedimentation of the culture media, respectively, and combined in one tube. The cells were washed twice with phosphate-buffered saline (PBS) and aliquots of the cells were stained with Trypan Blue solution. After the staining, cells were mounted in a hemocytometer for microscopic observation. Total cell number was determined by counting more than 300 cells per condition. The percentage of Trypan-Blue-stained cells (versus total cell number) was determined by calculation of data obtained with three independent counting of more than 100 cells. When nuclear morphology was evaluated, cells were grown and treated in glass-bottom dishes. After treatment, the cells were washed three times with PBS, fixed with 4% paraformaldehyde in PBS for 10 minutes, permeabilized with 0.2% Triton X-100 in PBS for 2 minutes and blocked with 3% BSA in PBS for 1 hour. Cells were then treated with propidium iodide at 2 μg/ml in PBS for 1 hour. After washing with PBS (three times 5 minutes), samples were mounted in PBS containing 50 mg/ml 1,4-diazabicyclo[2,2,2]octane and 90% glycerol and subjected to confocal microscopic observation. The fluorescence was detected at 543 nm argon excitation using optics of a 590 nm long-pass barrier filter.The fluorescent images were recorded and reconstituted with the use of software Adobe Photoshop CS [2].
别名benzylideneacetophenone, phenyl styryl ketone, Cinnamophenone, 查耳酮, benzalacetophenone, β-phenylacrylophenone
化学信息
分子量208.26
分子式C15H12O
CAS No.94-41-7
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度信息
DMSO: 55 mg/mL (264.09 mM)
H2O: 4.8 mM
溶液配制表
H2O/DMSO
1mg5mg10mg50mg
1 mM4.8017 mL24.0085 mL48.0169 mL240.0845 mL
DMSO
1mg5mg10mg50mg
5 mM0.9603 mL4.8017 mL9.6034 mL48.0169 mL
10 mM0.4802 mL2.4008 mL4.8017 mL24.0085 mL
20 mM0.2401 mL1.2004 mL2.4008 mL12.0042 mL
50 mM0.0960 mL0.4802 mL0.9603 mL4.8017 mL
100 mM0.0480 mL0.2401 mL0.4802 mL2.4008 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法:
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ,每只动物体重 20 g ,给药体积 100 μLTargetMol | Animal experiments 一共给药动物 10 只 ,您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent ( 母液浓度为 40 mg/mL ), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:50μLDMSOTargetMol | reagent 母液,添加 300 μLPEG300TargetMol | reagent 混匀澄清,再加 50μLTween 80, 混匀澄清,再加 600μLddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。

1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
%Tween 80
%ddH2O

剂量转换

对于不同动物的给药剂量换算,您也可以参考 更多

关键词

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