3-Isomangostin is an acetylcholinesterase selective inhibitor and a potent human aldose reductase inhibitor with an IC50 of 3.48 uM. 3-Isomangostin has free radical scavenging activity and inhibits MutT homolog 1 (MTH1) with an IC50 of 52 nM. It shows antiplasmodial activity with an IC50 values in the range of 4.71-11.40 uM. 3-Isomangostin can be used to develop anticancer agents as well.

MTH1:52 nM

非洲和亚洲传统医学，包括Ayurveda中的Garcinia种类被用于对抗疟疾。本研究识别了可食用Garcinia种中的抗疟原虫benzophenone和xanthone化合物，通过对Plasmodium falciparum的体外抑制活性测试进行鉴定。Garcinia xanthochymus、G. mangostana、G. spicata及G. livingstonei的整个果实被提取并测试其抗疟原虫活性。Garcinia xanthochymus经过生物活性引导的分级以识别活性分区。然后在疟原虫乳酸脱氢酶测定中筛选纯化的benzophenones (1-9)和xanthones (10-18)，并对哺乳动物(Vero)细胞的细胞毒性进行了测试。从G. xanthochymus中分离的benzophenones guttiferone E (4)、isoxanthochymol (5)和guttiferone H (6)及从G. mangostana中已知的xanthones α-mangostin (15)、β-mangostin (16)和3-Isomangostin (17)显示出抗疟原虫活性，IC50值范围为4.71-11.40 μM。Artemisinin和chloroquine作为阳性对照，展现的IC50值在0.01-0.24 μM范围内。