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IL-1R1 Protein, Cynomolgus, Recombinant (His)

产品编号 TMPY-03744

IL-1R1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.4 kDa and the accession number is G8F337.

IL-1R1 Protein, Cynomolgus, Recombinant (His)

IL-1R1 Protein, Cynomolgus, Recombinant (His)

产品编号 TMPY-03744
IL-1R1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.4 kDa and the accession number is G8F337.
规格价格库存数量
100 μg¥ 3,8205日内发货
1 mg¥ 24,9005日内发货
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产品信息

生物活性
Measured by its binding ability in a functional ELISA. Immobilized Human IL1RA at 2 μg/ml (100 μl/well) can bind Cynomolgus IL1R1 His, the EC50 of Cynomolgus IL1R1 His is 2.5-15 ng/mL.
产品描述
IL-1R1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.4 kDa and the accession number is G8F337.
种属
Cynomolgus
表达系统
HEK293 Cells
标签C-His
蛋白编号G8F337
别名
interleukin 1 receptor, type I
蛋白构建
A DNA sequence encoding the cynomolgus IL1R1 (EHH61701.1) (Met1-Thr332) was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: Asp 21
蛋白纯度
> 95 % as determined by SDS-PAGE
分子量37.4 kDa (predicted); 47-57 kDa (reducing conditions)
内毒素< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法
A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式In general, Lyophilized powders are shipping with blue ice.
研究背景
Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokines induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects. In the spleen, a slight increase in IL-1R ACP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess.

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