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X5050
还可以产品编号 T39974Cas号 2404756-81-4
X5050 is a REST inhibitor, with an EC 50 of 2.1 μM.
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X5050
还可以产品编号 T39974Cas号 2404756-81-4
X5050 is a REST inhibitor, with an EC 50 of 2.1 μM.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 2 mg | ¥ 1,470 | 5日内发货 | |
| 5 mg | ¥ 2,490 | 5日内发货 | |
| 25 mg | ¥ 9,160 | 6-8周 | |
| 50 mg | ¥ 11,900 | 6-8周 | |
| 100 mg | ¥ 18,700 | 6-8周 | |
| 1 mL x 10 mM (in DMSO) | ¥ 2,730 | 5日内发货 |
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产品介绍
生物活性
化学信息
| 产品描述 | X5050 is a REST inhibitor, with an EC 50 of 2.1 μM. |
| 体外活性 | X5050 (100 μM, 1 day) induces a dosedependent decrease in the REST isoform in protein level[1]. Western Blot Analysis[1]Cell Line: NSCs. Concentration: 100 μM. Incubation Time: One day. Result: Induced a dosedependent decrease in the 122 kDa longer REST isoform. |
| 体内活性 | X5050 (2 x 2μl of 20 mM) is active in HD pathological context[1]. Animal Model: 12-week-old male C57Bl6 mice[1].2 Dosage: 2 x 2μl of 20 mM in 10% DMSO in water. Administration: Intraventricular injection. Result: Increased BDNF expression. A decrease in Darpp32 and Snap25 expression was found by QRT-PCR in the lesioned striatum as compared with the contralateral striatum. Significantly increased the levels of Bdnf II splice variant (exon II containing variant) while Bdnf IV levels were not significantly changed. |
| 分子量 | 309.325 |
| 分子式 | C17H15N3O3 |
| CAS No. | 2404756-81-4 |
| 密度 | 1.323 g/cm3 (Predicted) |
储存&溶解度
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
剂量转换
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