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TRK-IN-28(compound 30f)作为一种TRK抑制剂,对TRKWT、TRKG595R和TRKG667C的IC50值具体表现为0.55 nM、25.1 nM和5.4 nM。同时,此化合物能够抑制多种细胞株的增殖,包括Ba/F3 - ETV6 -TRKAWT、Ba/F3-ETV6-TRKBWT、Ba/F3-LMNA-TRKG595R和Ba/F3-LMNA-TRKAG667C,其对应IC50值为9.5 nM、3.7 nM、205.0 nM和48.3 nM。
TRK-IN-28(compound 30f)作为一种TRK抑制剂,对TRKWT、TRKG595R和TRKG667C的IC50值具体表现为0.55 nM、25.1 nM和5.4 nM。同时,此化合物能够抑制多种细胞株的增殖,包括Ba/F3 - ETV6 -TRKAWT、Ba/F3-ETV6-TRKBWT、Ba/F3-LMNA-TRKG595R和Ba/F3-LMNA-TRKAG667C,其对应IC50值为9.5 nM、3.7 nM、205.0 nM和48.3 nM。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | TRK-IN-28 (compound 30f) functions as a TRK inhibitor, displaying potencies with IC 50 values of 0.55 nM for TRK WT, 25.1 nM for TRK G595R, and 5.4 nM for TRK G667C. Another TRK inhibitor, TRK-IN-2, exhibits antiproliferative effects with IC 50 values against multiple cell lines: 9.5 nM for Ba/F3-ETV6-TRKA WT, 3.7 nM for Ba/F3-ETV6-TRKB WT, 205.0 nM for Ba/F3-LMNA-TRK G595R, and 48.3 nM for Ba/F3-LMNA-TRKA G667C [1]. |
分子量 | 485.53 |
分子式 | C27H25F2N7 |
CAS No. | 2991504-43-7 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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