S1P1 Agonist III

Name: S1P1 Agonist III
Brand: TargetMol
SKU: T16833
Price: 283 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T16833Cas号 1324003-64-6

S1P1 Agonist III is an effective and orally active S1P1 agonist (EC50: 18 nM).

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S1P1 Agonist III

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产品编号 T16833Cas号 1324003-64-6

S1P1 Agonist III is an effective and orally active S1P1 agonist (EC50: 18 nM).

规格	价格	库存
2 mg	¥ 557	5日内发货
25 mg	¥ 4,610	6-8周
50 mg	¥ 5,990	6-8周
100 mg	¥ 9,240	6-8周
1 mL x 10 mM (in DMSO)	¥ 1,630	5日内发货

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产品介绍

生物活性

产品描述

S1P1 Agonist III is an effective and orally active S1P1 agonist (EC50: 18 nM).

体外活性

S1P1 agonist When dosed orally at 1 and 3 mg/kg, S1P1 Agonist III achieved a statistically significant lowering of circulating blood lymphocytes 24 h postdose. In rats, a dose-proportional increase in exposure was measured when S1P1 Agonist III was dosed orally at 2 and 100 mg/kg. S1P1 Agonist III displayed excellent pharmacokinetic parameters with low clearance (CL = 0.11 L/h/kg), long mean residence time (40 h), and good oral bioavailability (F = 67%).

化学信息

分子量	415.37
分子式	C₂₁H₁₆F₃N₃O₃
CAS No.	1324003-64-6
密度	1.354 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 62.5 mg/mL (150.47 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4075 mL	12.0375 mL	24.0749 mL	120.3746 mL
5 mM	0.4815 mL	2.4075 mL	4.8150 mL	24.0749 mL
10 mM	0.2407 mL	1.2037 mL	2.4075 mL	12.0375 mL
20 mM	0.1204 mL	0.6019 mL	1.2037 mL	6.0187 mL
50 mM	0.0481 mL	0.2407 mL	0.4815 mL	2.4075 mL
100 mM	0.0241 mL	0.1204 mL	0.2407 mL	1.2037 mL