S-MGB-234

Name: S-MGB-234
Brand: TargetMol
SKU: T39397
Price: 3220 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T39397Cas号 1970223-53-0

S-MGB-234 is a minor groove binder utilized for the treatment of Animal African Trypanosomiasis (AAT). It exhibits exceptional in vitro efficacy against the primary causative agents of AAT, namely Trypanosoma congolense and Trypanosoma vivax. Moreover, S-MGB-234 does not demonstrate cross-resistance with existing diamidine drugs and is not internalized through the transporters employed by diamidines.

S-MGB-234

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产品编号 T39397Cas号 1970223-53-0

规格	价格	库存	数量
25 mg	¥ 10,600	期货

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产品介绍

生物活性

产品描述	S-MGB-234 is a minor groove binder utilized for the treatment of Animal African Trypanosomiasis (AAT). It exhibits exceptional in vitro efficacy against the primary causative agents of AAT, namely Trypanosoma congolense and Trypanosoma vivax. Moreover, S-MGB-234 does not demonstrate cross-resistance with existing diamidine drugs and is not internalized through the transporters employed by diamidines.
体外活性	S-MGB-234 (compound 7) (69 hours) shows nontoxic to L6 cells with an EC 50 of 20.39 μM[1].
体内活性	S-MGB-234 (compound 7) provides total cure and no relapses in mice (cured/infected, 4/4), when treated with 2 applications of 50 mg/kg i.p.. Partial cure (1/4) is seen in mice treated with four daily applications of 10 mg/kg i.p., whilst only two applications of S-MGB-234 (compound 7) at 10 mg/kg i.p. gives no cure but prolongs survival relative to the untreated control[1].