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rTRD01为TDP-43配体,与TDP-43的RRM1和RRM2结构域结合(Kd=89 uM,TDP-43102-269)。该化合物能够削弱TDP-43与与疾病相关的c9orf72基因的六核苷酸RNA的交互作用,可作为神经退行性疾病研究的工具。
rTRD01为TDP-43配体,与TDP-43的RRM1和RRM2结构域结合(Kd=89 uM,TDP-43102-269)。该化合物能够削弱TDP-43与与疾病相关的c9orf72基因的六核苷酸RNA的交互作用,可作为神经退行性疾病研究的工具。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | 询价 | 8-10周 | |
50 mg | 询价 | 8-10周 |
产品描述 | rTRD01 is a TDP-43 ligand that selectively binds to the RRM1 and RRM2 domains of TDP-43, exhibiting a dissociation constant (Kd) of 89 µM for TDP-43 102–269. This compound is capable of partially disrupting the interaction between TDP-43 and the hexanucleotide RNA repeat associated with the c9orf72 gene, which is implicated in certain neurodegenerative diseases. rTRD01 holds potential for use in neurodegenerative disease research [1]. |
分子量 | 344.38 |
分子式 | C18H21FN4O2 |
CAS No. | 1332175-56-0 |
存储 | Shipping with blue ice. |
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