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PLX7922, a RAF inhibitor, demonstrates binding affinity with BRAF V600E and exhibits inhibitory effects on pERK in BRAF V600E cell lines, while inducing pERK activation in mutant NRAS cell lines.
PLX7922, a RAF inhibitor, demonstrates binding affinity with BRAF V600E and exhibits inhibitory effects on pERK in BRAF V600E cell lines, while inducing pERK activation in mutant NRAS cell lines.
产品描述 | PLX7922, a RAF inhibitor, demonstrates binding affinity with BRAF V600E and exhibits inhibitory effects on pERK in BRAF V600E cell lines, while inducing pERK activation in mutant NRAS cell lines. |
体外活性 | PLX7922 (1-1000 nM) inhibits pERK in BRAF V600E cell lines, activates pERK in mutant NRAS cell lines (B9 and IPC-298)[1]. |
别名 | PLX7922 |
分子量 | 464.58 |
分子式 | C20H25FN6O2S2 |
CAS No. | 1638772-61-8 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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