PhiKan 083 hydrochloride

Name: PhiKan 083 hydrochloride
Brand: TargetMol
SKU: T16523
Price: 397 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T16523Cas号 1050480-30-2

PhiKan 083 hydrochloride is a carbazole derivative. Which binds to the surface cavity and stabilizes Y220C (Kd: 167 μM). It also a relative binding affinity (Kd) of 150 μM in Ln229 cells.

PhiKan 083 hydrochloride

还可以

产品编号 T16523Cas号 1050480-30-2

PhiKan 083 hydrochloride is a carbazole derivative. Which binds to the surface cavity and stabilizes Y220C (Kd: 167 μM). It also a relative binding affinity (Kd) of 150 μM in Ln229 cells.

规格	价格	库存	数量
10 mg	¥ 4,320	35日内发货

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产品介绍

生物活性

产品描述	PhiKan 083 hydrochloride is a carbazole derivative. Which binds to the surface cavity and stabilizes Y220C (Kd: 167 μM). It also a relative binding affinity (Kd) of 150 μM in Ln229 cells.
靶点活性	p53-Y220C:（kd）167 μM
体外活性	PhiKan 083 slows down its thermal denaturation rate. PhiKan 083 shows a relative binding affinity (Kd) of 150 μM for p53Y220C in Ln229 cells. PhiKan 083 (100 μM) in combination with NSC 123127 (1 μM) increases the pro-apoptotic activity in all variants of Ln229 cells (p53wt, p53Y220C, p53G245S, p53R282W). PhiKan 083 (125 μM, 48 hours) decreases the cell viability of engineered variants of Ln229 cells [2][3].