PF-05198007

Name: PF-05198007
Brand: TargetMol
SKU: T16485
Rating: 4.5 (1 reviews)

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产品编号 T16485Cas号 1235406-19-5

PF-05198007 is a compound with a similar pharmacodynamic profile to PF-05089771. PF-05198007 is an effective and selective arylsulfonamide Nav1.7 inhibitor.

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PF-05198007

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产品编号 T16485Cas号 1235406-19-5

PF-05198007 is a compound with a similar pharmacodynamic profile to PF-05089771. PF-05198007 is an effective and selective arylsulfonamide Nav1.7 inhibitor.

规格	价格	库存
2 mg	¥ 915	5日内发货
5 mg	¥ 1,530	6-8周
10 mg	¥ 1,980	6-8周
100 mg	¥ 7,990	6-8周
1 mL x 10 mM (in DMSO)	¥ 1,780	6-8周

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产品描述	PF-05198007 is a compound with a similar pharmacodynamic profile to PF-05089771. PF-05198007 is an effective and selective arylsulfonamide Nav1.7 inhibitor.
体外活性	PF-05198007 (30 nM) blocks on average 83.0 ± 2.7% of the total TTX-S current. This shows the major TTX-S conductance is carried through Nav1.7 channels in small-diameter mouse DRG neurons (n = 35)[1].
体内活性	PF-05198007 (1 or 10 mg/kg, orally) decreases the capsaicin flare response in WT. However, it not reduces Nav1.7Nav1.8Cre mice[1].