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Mirk-IN-1 is an effective inhibitor of Dyrk1B(Mirk kianse) and Dyrk1A (IC50: 68±48 nM and 22±8 nM respectively).
Mirk-IN-1 is an effective inhibitor of Dyrk1B(Mirk kianse) and Dyrk1A (IC50: 68±48 nM and 22±8 nM respectively).
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥ 2,540 | 5日内发货 | |
50 mg | 询价 | 6-8周 | |
100 mg | 询价 | 6-8周 | |
1 mL x 10 mM (in DMSO) | ¥ 5,442 | 5日内发货 |
产品描述 | Mirk-IN-1 is an effective inhibitor of Dyrk1B(Mirk kianse) and Dyrk1A (IC50: 68±48 nM and 22±8 nM respectively). |
体外活性 | Dyrk inhibitor Mirk-IN-1 had an EC50 of 1.9 ±0.2 mmol/L on SW620 cells. Mirk-IN-1 inhibited the activities of DYRK1A, ABL, FLT3, and MARK1 by 88%, 64%, 56%, and 73%, respectively, at a much higher concentration of 10 mmol/L in a kinase assay [1]. Mirk-IN-1 was able to block tumour cells from undergoing reversible arrest in a quiescent G0 state and enable some cells to exit quiescence [2]. |
别名 | Dyrk1B/A-IN-1 |
分子量 | 498.32 |
分子式 | C23H17Cl2N5O4 |
CAS No. | 1386979-55-0 |
密度 | 1.51 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
溶解度信息 | DMSO: 5 mg/mL (10.03 mM), Sonication is recommended. | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
DMSO
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