MEY-003, an Autotaxin (ATX) inhibitor, exhibits EC50 values of 460 nM for hATX-β and 1.09 μM for hATX-ɣ (analysis with LPC18:1), demonstrating its potency against these isoforms. It acts non-competitively with a K i of 432 nM, making it suitable for research into diseases where ATX is implicated [1].

MEY-003（10 μM，30 min）通过阻断HeLa细胞的LPA信号通路以及抑制LPA1受体的内化作用来发挥其活性[1]。