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Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK, LYN, SYK, and TXK (IC50s: 13nM, 9nM, 3nM, 26nM, and 2nM for Lck, Btk, Lyn, Btk, and Txk respectively).
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Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK, LYN, SYK, and TXK (IC50s: 13nM, 9nM, 3nM, 26nM, and 2nM for Lck, Btk, Lyn, Btk, and Txk respectively).
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥ 720 | 5日内发货 | |
5 mg | ¥ 1,230 | 5日内发货 | |
25 mg | ¥ 4,350 | 6-8周 | |
50 mg | ¥ 5,660 | 6-8周 | |
100 mg | ¥ 7,890 | 6-8周 | |
1 mL x 10 mM (in DMSO) | ¥ 1,370 | 5日内发货 |
产品描述 | Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK, LYN, SYK, and TXK (IC50s: 13nM, 9nM, 3nM, 26nM, and 2nM for Lck, Btk, Lyn, Btk, and Txk respectively). |
体外活性 | A further 27 kinases were bound with %control < 10. Kd values for 16 kinases were determined and found to be below 100 nM. These included TXK (10 nM). Src family kinase Lck inhibitor 2 inhibited 48 kinases with %control < 1 (33 of them tyrosine kinases, almost half of the 71 tyrosine kinases in the panel) [2]. |
分子量 | 335.36 |
分子式 | C18H17N5O2 |
CAS No. | 944795-06-6 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 20 mg/mL (59.64 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
DMSO
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