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hCA I-IN-4 (Compound 14) 是一种碳酸酐酶(carbonic anhydrase)和胆碱酯酶(cholinesterase)的抑制剂,能够抑制hCA I、hCA II、AChE和BChE,其抑制常数Ki分别为29.94 nM、17.72 nM、21.21 nM和7.65 nM。在BT-549细胞中,hCA I-IN-4 展现出细胞毒性,半数抑制浓度(IC50)为16.59 μM。
hCA I-IN-4 (Compound 14) 是一种碳酸酐酶(carbonic anhydrase)和胆碱酯酶(cholinesterase)的抑制剂,能够抑制hCA I、hCA II、AChE和BChE,其抑制常数Ki分别为29.94 nM、17.72 nM、21.21 nM和7.65 nM。在BT-549细胞中,hCA I-IN-4 展现出细胞毒性,半数抑制浓度(IC50)为16.59 μM。
产品描述 | hCA I-IN-4 (Compound 14) is an inhibitor of carbonic anhydrase and cholinesterase, effectively inhibiting hCA I, hCA II, AChE, and BChE with Ki values of 29.94 nM, 17.72 nM, 21.21 nM, and 7.65 nM, respectively. It also demonstrates cytotoxicity in BT-549 cells, with an IC50 of 16.59 μM. |
靶点活性 | BChE:7.65 nM (Ki), CA II (human):17.72 nM (Ki), AChE:21.21 nM (Ki), CA I (human):29.94 nM (Ki) |
分子量 | 351.4 |
分子式 | C22H17N5 |
CAS No. | 3054159-56-4 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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