EG01377

Name: EG01377
Brand: TargetMol
SKU: T11154
Price: -1 USD
Availability: InStock
Rating: 4.5 (1 reviews)

产品编号 T11154Cas号 2227996-00-9

EG01377 has antiangiogenic, antimigratory, and antitumor effects.EG01377 is a neuropilin-1 (NRP1) antagonist, with a Kd of 1.32 μM for NRP1-b1, and IC50s of both 609 nM for NRP1-a1 and NRP1-b1, but shows no effect on NRP2.

EG01377

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产品编号 T11154Cas号 2227996-00-9

规格	价格	库存
25 mg	¥ 13,900	1-2周
50 mg	¥ 18,300	1-2周
100 mg	¥ 23,500	1-2周

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产品介绍

生物活性

产品描述	EG01377 has antiangiogenic, antimigratory, and antitumor effects.EG01377 is a neuropilin-1 (NRP1) antagonist, with a Kd of 1.32 μM for NRP1-b1, and IC50s of both 609 nM for NRP1-a1 and NRP1-b1, but shows no effect on NRP2.
靶点活性	NRP1-b1:(kd)1.32 μM , NRP1-b1:609 nM , NRP1-a1:609 nM
体外活性	EG01377 inhibits NRP1 in DU145/cells.Ad.NRP1 cells (IC50, 1.6 μM). EG01377 (3, 10, and 30 μM) inhibits VEGF-A stimulated tyrosine phosphorylation of VEGF-R2/KDR. EG01377 (30 μM) also significantly reduces HUVEC cell migration in response to VEGFA, and reduces VEGF-induced angiogenesis. Moreover, EG01377 (30 μM) in combination with VEGFA causes reduction in A375P spheroid outgrowth. EG01377 blocks the production of TGFβ by Nrp1+ Tregs in the presence of tumor cell-derived factors.EG01377 is a neuropilin-1 (NRP1) antagonist, with a Kd of 1.32 μM for NRP1-b1, and IC50s of both 609 nM for NRP1-a1 and NRP1-b1, but shows no effect on NRP2.