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DPP-8/9 probe-1 (compound 20) 是一种针对DPP8/9的荧光探针,其特点是含有硝基苯并恶二唑 (NBD) 标签,能在体外通过荧光显微镜高选择性地标记并可视化活跃的DPP8/9。该化合物对DPP8/9显示出较高的亲和力与选择性,与S9家族其他成员相比,其IC50值分别为210 nM和15 nM。
DPP-8/9 probe-1 (compound 20) 是一种针对DPP8/9的荧光探针,其特点是含有硝基苯并恶二唑 (NBD) 标签,能在体外通过荧光显微镜高选择性地标记并可视化活跃的DPP8/9。该化合物对DPP8/9显示出较高的亲和力与选择性,与S9家族其他成员相比,其IC50值分别为210 nM和15 nM。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 待询 | |
50 mg | 询价 | 待询 |
产品描述 | DPP-8/9 probe-1 (compound 20) is a fluorescent probe designed to specifically target and label Dipeptidyl Peptidase DPP8/9, allowing for its visualization through fluorescence microscopy in vitro when active. This compound incorporates a nitrobenzoxadiazole (NBD) tag, demonstrating a high affinity and selectivity for DPP8/9, with significant preference over other S9 family enzymes, evidenced by IC 50 values of 210 nM and 15 nM, respectively. [9] [1] |
靶点活性 | DPP-4:44 μM, DPP-8:210 nM, DPP-9:15 nM |
体外活性 | DPP-8/9 probe-1 (compound 20) (10 μM; 30 min) effectively stains and visualizes DPP-8/9 in THP-1 monocyte cells [1]. Using immunofluorescence [1], the experiment indicates that lower concentrations (0.5 μM, 1 μM, and 2 μM) are insufficient for adequate in-cell staining. Optimal results are achieved at a concentration of 10 μM, where visualization is markedly improved. |
分子量 | 637.66 |
分子式 | C31H36FN7O7 |
CAS No. | 3020859-80-4 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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