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68Ga-DOTA-NT-20.3是一种神经降压素(NTS)类似物,也是68Ga离子的配体。在PET成像中,68Ga-DOTA-NT-20.3展示了快速的肿瘤摄取及肿瘤与背景之间的高对比度,血液清除速度快,肾脏中的积累适中。其药代动力学和生物分布特性有利,能在携带皮下或原位移植人类胰腺癌的小鼠中产生高品质的PET图像。68Ga-DOTA-NT-20.3对胰腺癌细胞的NTSR1有特异性结合,并且在腺癌的PET检测中表现优于18F-FDG。
68Ga-DOTA-NT-20.3是一种神经降压素(NTS)类似物,也是68Ga离子的配体。在PET成像中,68Ga-DOTA-NT-20.3展示了快速的肿瘤摄取及肿瘤与背景之间的高对比度,血液清除速度快,肾脏中的积累适中。其药代动力学和生物分布特性有利,能在携带皮下或原位移植人类胰腺癌的小鼠中产生高品质的PET图像。68Ga-DOTA-NT-20.3对胰腺癌细胞的NTSR1有特异性结合,并且在腺癌的PET检测中表现优于18F-FDG。
规格 | 价格 | 库存 | 数量 |
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10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | 68Ga-DOTA-NT-20.3 is an analogue of neurotensin (NTS) and acts as a ligand for 68Ga ions. In PET imaging, it demonstrates rapid tumor uptake and high contrast between tumor and background, along with fast clearance from the blood and moderate accumulation in the kidneys. Its pharmacokinetic and biodistribution properties are advantageous, producing high-quality PET images in mice with subcutaneous or orthotopic human pancreatic cancer xenografts. 68Ga-DOTA-NT-20.3 specifically binds to NTSR1 on pancreatic cancer cells and outperforms 18F-FDG in PET detection of adenocarcinoma. |
别名 | Ac-Lys-Pro-N-Me-Arg-Arg-Pro-Tyr-Tle-Leu-OH |
分子量 | 1484.74 |
分子式 | C68H113N19O18 |
CAS No. | 1262311-97-6 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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