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Celgosivir hydrochloride

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产品编号 T10755Cas号 141117-12-6
别名 MX3253 hydrochloride, MDL 28574 hydrochloride, MBI 3253 hydrochloride

Celgosivir hydrochloride (MBI 3253 hydrochloride) is an α-glucosidase I inhibitor and inhibits bovine viral diarrhoea virus (BVDV) (IC50: 1.27 μM).

Celgosivir hydrochloride

Celgosivir hydrochloride

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产品编号 T10755 别名 MX3253 hydrochloride, MDL 28574 hydrochloride, MBI 3253 hydrochlorideCas号 141117-12-6

Celgosivir hydrochloride (MBI 3253 hydrochloride) is an α-glucosidase I inhibitor and inhibits bovine viral diarrhoea virus (BVDV) (IC50: 1.27 μM).

规格价格库存数量
2 mg
¥ 1,820
5日内发货
5 mg
¥ 3,320
5日内发货
25 mg
¥ 11,600
1-2周
50 mg
¥ 15,100
1-2周
100 mg
¥ 21,500
1-2周
1 mL x 10 mM (in DMSO)
¥ 3,970
5日内发货
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产品介绍

生物活性
产品描述
Celgosivir hydrochloride (MBI 3253 hydrochloride) is an α-glucosidase I inhibitor and inhibits bovine viral diarrhoea virus (BVDV) (IC50: 1.27 μM).
靶点活性
α-glucosidase I:1.27 μM
体外活性
Celgosivir is more effective (IC50: 20 μM) than the parent molecule (IC50: 254 μM) at causing the accumulation of glucosylated oligosaccharides in HIV-infected cells by inhibition of glycoprotein processing. Celgosivir exhibits potent antiviral activity against HIV-1 (IC50: 2.0 μM) [1]. BVDV is a closely related virus of hepatitis C virus (HCV). Celgosivir inhibits BVDV with IC50 values of 16 and 47 μM in plaque assay and cytopathic effect assay, respectively [2]. Celgosivir inhibits DENV2 replication with an EC50 of 0.2 μM. The EC50 values against DENV1, 3, and 4 are less than 0.7 μM [3].
体内活性
During primary infection with a mouse-adapted DENV strain S221, mice show increased viremia on day 3, yet 80% survived day 10 with a virus completely cleared by day 8 [3]. Celgosivir (50 mg/kg, BID for 5 days) fully protects AG129 mice from lethal infection with a mouse-adapted dengue virus and is effective even after 48 h delayed treatment. The protection by celgosivir is dose- and schedule-dependent and that a twice-a-day regimen of 50, 25, or 10 mg/kg is more protective than a single daily dose of 100 mg/kg. Pharmacokinetics studies of celgosivir in mice show that it rapidly metabolizes to castanospermine [4].
别名MX3253 hydrochloride, MDL 28574 hydrochloride, MBI 3253 hydrochloride
化学信息
分子量295.76
分子式C12H22ClNO5
CAS No.141117-12-6
密度1.31g/cm3
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度信息
H2O: 100 mg/mL (338.11 mM), Sonication is recommended.
DMSO: 100 mg/mL (338.11 mM), Sonication is recommended.
溶液配制表
H2O/DMSO
1mg5mg10mg50mg
1 mM3.3811 mL16.9056 mL33.8112 mL169.0560 mL
5 mM0.6762 mL3.3811 mL6.7622 mL33.8112 mL
10 mM0.3381 mL1.6906 mL3.3811 mL16.9056 mL
20 mM0.1691 mL0.8453 mL1.6906 mL8.4528 mL
50 mM0.0676 mL0.3381 mL0.6762 mL3.3811 mL
100 mM0.0338 mL0.1691 mL0.3381 mL1.6906 mL

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  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法:
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ,每只动物体重 20 g ,给药体积 100 μLTargetMol | Animal experiments 一共给药动物 10 只 ,您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent ( 母液浓度为 40 mg/mL ), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:50μLDMSOTargetMol | reagent 母液,添加 300 μLPEG300TargetMol | reagent 混匀澄清,再加 50μLTween 80, 混匀澄清,再加 600μLddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。

1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
%Tween 80
%ddH2O

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