Bromodiphenhydramine (Ambodryl) has antimicrobial activities which can be used in the cutaneous allergies research. Bromodiphenhydramine is an effective antihistamine that can inhibit a large number of Gram-negative and Gram-positive bacteria [1] [2] [3].

Bromodiphenhydramine (1.5 and 3 μg/g, single) protects mice against a challenge with a virulent strain of Salmonella typhimurium, and also significantly reduces the multiplication of this organism in the liver, spleen and blood of the protected animals in comparison with the unprotected controls [2].