BF-168

Name: BF-168
Brand: TargetMol
SKU: T10529
Rating: 4.5 (1 reviews)

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产品编号 T10529Cas号 634911-47-0

BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).

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产品编号 T10529Cas号 634911-47-0

BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).

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生物活性

产品描述	BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).
靶点活性	β-Amyloid (1–42):ki： 6.4 nM
体外活性	BF-168 is a potent agent that selectively recognizes SPs and NFTs in AD brain. BF-168 is a candidate probe for PET and is found to specifically recognize both neuritic and diffuse plaques.
体内活性	Intravenous injection of BF-168 in PS1/APP and APP23 transgenic mice results in specific in vivo labeling to both compact and diffuse amyloid deposits in the brain. In addition, 18F-radiolabeled BF-168 demonstrates abundant initial brain uptake (3.9% injected dose/gm at 2 min after injection) and fast clearance (t1/2=24.7 min) after intravenous administration in normal mice.