ATIC-IN-1 (compound 14) serves as an inhibitor specifically aimed at the dimerization of Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC), with a K i of 685 nM. This dimerization is essential for the enzyme's aminoimidazole carboxamide ribonucleotide (AICAR) transformylase function. Furthermore, ATIC-IN-1 demonstrates anti-tumor properties by diminishing both cell proliferation and cell division rates [1].

ATIC-IN-1（10 μM, 50 μM）作为特异性抑制剂，在有或无1 mg/mL及10 mg/mL BSA情况下均展现出非特异性聚集机制[1]。