As-358 hydrochloride

Name: As-358 hydrochloride
Brand: TargetMol
SKU: T60959
Price: 1080 USD
Availability: InStock
Rating: 4.5 (1 reviews)

还可以

产品编号 T60959Cas号 2374723-26-7

As-358 (hydrochloride) 显示出良好的体内安全性，并且抑制埃博拉病毒和马尔堡病毒，IC50值分别为 9.1 μM 和 18.1 μM。

还可以

产品编号 T60959Cas号 2374723-26-7

As-358 (hydrochloride) 显示出良好的体内安全性，并且抑制埃博拉病毒和马尔堡病毒，IC50值分别为 9.1 μM 和 18.1 μM。

大包装 & 定制

加入购物车

实验操作小课堂

联系我们获取更多批次信息

资源下载

TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

产品介绍

生物活性

产品描述	As-358 (hydrochloride) shows well in vivo safety as well as inhibits Ebola virus and Marburg virus with IC 50 values of 9.1 μM and 18.1 μM [1].
体外活性	As-358 (hydrochloride) (compound 3b·HCl) (0-500 μM) exhibits inhibitory activities against EBOV and MARV [1]. Cell Proliferation Assay Cell Line: Vero (infected with EBOV and MARV) [1] Concentration: 0-500 μM Incubation Time: 10 days Result: Exhibits inhibitory activities against EBOV and MARV, with IC 50 s of 18.1 ± 9.3 μM and 9.1 ± 2.1 μM, SI values of 15 and 31, respectively.
体内活性	As-358 (hydrochloride) (0.14-1.08 g/kg; IG; single) exhibits no toxicity to adult mice with intragastric administration [1]. Animal Model: ICR mice [1] Dosage: 1.08, 0.44, 0.27, and 0.14 g/kg Administration: IG; single (observed for 7 days) Result: Exhibited no toxicity to adult mice with intragastric administration, and the LD 50 > 1000 mg/kg.