Arcopilin A (compound Arcopilin A(1)) functions as an antibacterial agent with moderate inhibitory capabilities against fungal pathogens and Gram-positive bacteria, exhibiting IC 50 values of 8.9 μg/mL for KB-3-1 cells and 14 μg/mL for L929 cells. Notably, it can effectively eradicate preformed biofilms of Staphylococcus aureus. Additionally, Arcopilin A significantly boosts the efficacy of gentamicin (GM) and vancomycin (Vac), enhancing their activities by 115 and 31 times, respectively.

Arcopilin A 在浓度范围15.6-250 μg/mL下，可约50-60%地破坏预成型生物膜，并能在3.9至7.8 μg/mL的低浓度抑制金黄色葡萄球菌生长。对于B.subtilis DSM 10、S.aureus DSM 346、S.pombe DSM 70572、C.albicans DSM 1665、M.hiemalis DSM 2656，Arcopilin A 的最小抑菌浓度（MIC）均为66.7 μg/mL；对S.aureus DSM 1104，其MIC值为31.3 μg/mL。在3.9-31.1 μg/mL浓度下，Arcopilin A 能降低生物膜的代谢活性，显示出剂量依赖性。此外，Arcopilin A 在2-7.8 μg/mL的浓度下能抑制金黄色葡萄球菌 DSM 1104 的浮游细胞生长。当与GM及Vac联用时，Arcopilin A 在3.9-7.8 μg/mL，24小时的处理下，可以显著增强这两种抗生素的效力，使MIC值分别从15.6降至0.13 μg/mL和从2降至0.065 μg/mL，效力分别提高了115倍和31倍。