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Anti-TYRO3 Monoclonal Antibody-AF647

产品编号 TMAZ-0193A6
别名 Tyrosine-protein kinase BYK, Tyrosine-protein kinase DTK, Tyrosine-protein kinase SKY, Tyrosine-protein kinase receptor TYRO3, Tyrosine-protein kinase RSE, Tyrosine-protein kinase TIF

Anti-TYRO3 Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting TYRO3. Anti-TYRO3 Monoclonal Antibody-AF647 can be used in ELISA, FACS, IF.

Anti-TYRO3 Monoclonal Antibody-AF647

Anti-TYRO3 Monoclonal Antibody-AF647

纯度: 无数据
产品编号 TMAZ-0193A6 别名 Tyrosine-protein kinase BYK, Tyrosine-protein kinase DTK, Tyrosine-protein kinase SKY, Tyrosine-protein kinase receptor TYRO3, Tyrosine-protein kinase RSE, Tyrosine-protein kinase TIF

Anti-TYRO3 Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting TYRO3. Anti-TYRO3 Monoclonal Antibody-AF647 can be used in ELISA, FACS, IF.

规格价格库存数量
25 μg¥ 2,087.42¥ 3,5997日内发货
50 μg¥ 3,478.84¥ 5,9987日内发货
100 μg¥ 5,218.26¥ 8,9977日内发货
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产品介绍

生物活性
产品描述
Anti-TYRO3 Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting TYRO3. Anti-TYRO3 Monoclonal Antibody-AF647 can be used in ELISA, FACS, IF.
别名Tyrosine-protein kinase BYK, Tyrosine-protein kinase DTK, Tyrosine-protein kinase SKY, Tyrosine-protein kinase receptor TYRO3, Tyrosine-protein kinase RSE, Tyrosine-protein kinase TIF
Ig Type
Rabbit monoclonal IgG
交叉反应
Human
验证活性
Flow cytometry analysis of TYRO3 overexpressed 295F cells with TMAZ-0193A6, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line).
应用
ELISA, FACS, IF
推荐剂量
0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Single-pass type I membrane
构建方式This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of TYRO3 protein.
纯化方式Protein A Affinity Purified
性状Liquid
缓冲液0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin.
纯度> 95% as determined by SDS-PAGE.
研究背景Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3|(Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope|(Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope
偶联与修饰
偶联
AF647
其他可选修饰符
Biotin/APC/PE/AF488/AF555
可提供抗体种类
1
抗原信息
免疫原
TYRO3
抗原种属
Human
基因ID
7301
Uniprot ID
研究领域
Drug Target
化学信息
分子量150 kDa
存储&运输
储存方式For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze.
运输方式For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice.

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