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Anti-PD-1 Monoclonal Antibody-Biotin

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产品编号 TMAZ-0006B
别名 Programmed cell death protein 1

Anti-PD-1 Monoclonal Antibody-Biotin is a Biotin-conjugated rabbit antibody targeting PD-1. Anti-PD-1 Monoclonal Antibody-Biotin can be used in ELISA, FACS.

Anti-PD-1 Monoclonal Antibody-Biotin

Anti-PD-1 Monoclonal Antibody-Biotin

Rating icon 还可以
产品编号 TMAZ-0006B 别名 Programmed cell death protein 1

Anti-PD-1 Monoclonal Antibody-Biotin is a Biotin-conjugated rabbit antibody targeting PD-1. Anti-PD-1 Monoclonal Antibody-Biotin can be used in ELISA, FACS.

规格价格库存数量
25 μg¥ 3,5997日内发货
50 μg¥ 5,9987日内发货
100 μg¥ 8,9977日内发货
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产品介绍

生物活性
产品描述
Anti-PD-1 Monoclonal Antibody-Biotin is a Biotin-conjugated rabbit antibody targeting PD-1. Anti-PD-1 Monoclonal Antibody-Biotin can be used in ELISA, FACS.
别名Programmed cell death protein 1
Ig Type
Rabbit monoclonal IgG
交叉反应
Human
验证活性
Flow cytometry analysis of PD-1 overexpressed 417F cells with TMAZ-0006B, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line).
应用
ELISA, FACS
推荐剂量
0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Single-pass type I membrane
构建方式This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of PD-1 protein.
纯化方式Protein A Affinity Purified
性状Liquid
缓冲液0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin.
纯度> 95% as determined by SDS-PAGE.
研究背景Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed: 21276005). Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed: 21276005). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (By similarity)|The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed: 28951311). The interaction with CD274/PDCD1L1 inhibits cytotoxic T lymphocytes (CTLs) effector function (PubMed: 28951311). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (PubMed: 22658127, PubMed: 25034862, PubMed: 25399552)
偶联与修饰
偶联
Biotin
其他可选修饰符
APC/PE/AF488/AF555/AF647
可提供抗体种类
3
抗原信息
免疫原
PD-1
抗原种属
Human
基因ID
5133
Uniprot ID
研究领域
Immunology Research
化学信息
分子量150 kDa
存储&运输
储存方式For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze.
运输方式For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice.

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