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Anti-ITGB1 Monoclonal Antibody-Biotin

产品编号 TMAZ-0034B
别名 VLA-4 subunit beta, Fibronectin receptor subunit beta, Integrin beta-1, Glycoprotein IIa

Anti-ITGB1 Monoclonal Antibody-Biotin is a Biotin-conjugated rabbit antibody targeting ITGB1. Anti-ITGB1 Monoclonal Antibody-Biotin can be used in ELISA, FACS.

Anti-ITGB1 Monoclonal Antibody-Biotin

Anti-ITGB1 Monoclonal Antibody-Biotin

纯度: 无数据
产品编号 TMAZ-0034B 别名 VLA-4 subunit beta, Fibronectin receptor subunit beta, Integrin beta-1, Glycoprotein IIa

Anti-ITGB1 Monoclonal Antibody-Biotin is a Biotin-conjugated rabbit antibody targeting ITGB1. Anti-ITGB1 Monoclonal Antibody-Biotin can be used in ELISA, FACS.

规格价格库存数量
25 μg¥ 2,296.22¥ 3,9597日内发货
50 μg¥ 3,826.84¥ 6,5987日内发货
100 μg¥ 5,740.26¥ 9,8977日内发货
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产品介绍

生物活性
产品描述
Anti-ITGB1 Monoclonal Antibody-Biotin is a Biotin-conjugated rabbit antibody targeting ITGB1. Anti-ITGB1 Monoclonal Antibody-Biotin can be used in ELISA, FACS.
别名VLA-4 subunit beta, Fibronectin receptor subunit beta, Integrin beta-1, Glycoprotein IIa
Ig Type
Rabbit monoclonal IgG
交叉反应
Human
验证活性
Flow cytometry analysis of ITGB1 overexpressed 332F cells with TMAZ-0034B, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line).
应用
ELISA, FACS
推荐剂量
0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Single-pass type I membrane
构建方式This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of ITGB1 protein.
纯化方式Protein A Affinity Purified
性状Liquid
缓冲液0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin.
纯度> 95% as determined by SDS-PAGE.
研究背景Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6: ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4: ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed: 23125415, PubMed: 24789099). ITGA4: ITGB1 and ITGA5: ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed: 18635536, PubMed: 25398877). ITGA5: ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed: 12807887, PubMed: 17158881). ITGA5: ITGB1 acts as a receptor for fibronectin FN1 and mediates R-G-D-dependent cell adhesion to FN1 (PubMed: 33962943). ITGA5: ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed: 29030430). ITGA5: ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed: 31331973). Plays an important role in myoblast differentiation and fusion during skeletal myogenesis (By similarity). ITGA9: ITGB1 may play a crucial role in SVEP1/polydom-mediated myoblast cell adhesion (By similarity). Integrins ITGA9: ITGB1 and ITGA4: ITGB1 repress PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via their interaction with SVEP1, thereby inhibit vasocontraction (PubMed: 35802072)|Interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro)|Isoform 5 displaces isoform 1 in striated muscles|(Microbial infection) Integrin ITGA2: ITGB1 acts as a receptor for Human echoviruses 1 and 8|(Microbial infection) Acts as a receptor for Cytomegalovirus/HHV-5|(Microbial infection) Acts as a receptor for Epstein-Barr virus/HHV-4|(Microbial infection) Integrin ITGA5: ITGB1 acts as a receptor for Human parvovirus B19|(Microbial infection) Integrin ITGA2: ITGB1 acts as a receptor for Human rotavirus|(Microbial infection) Acts as a receptor for Mammalian reovirus|(Microbial infection) In case of HIV-1 infection, integrin ITGA5: ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions|(Microbial infection) Interacts with CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi (PubMed: 32487760). Integrin ITGA3: ITGB1 may act as a receptor for R.delemar CotH7 in alveolar epithelial cells, which may be an early step in pulmonary mucormycosis disease progression (PubMed: 32487760)|(Microbial infection) May serve as a receptor for adhesin A (nadA) of N.meningitidis
偶联与修饰
偶联
Biotin
其他可选修饰符
APC/PE/AF488/AF555/AF647
可提供抗体种类
5
抗原信息
免疫原
ITGB1
抗原种属
Human
基因ID
3688
Uniprot ID
研究领域
Immunology Research
化学信息
分子量150 kDa
存储&运输
储存方式For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze.
运输方式For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice.

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