购物车
  • 全部删除
  • TargetMol
    您的购物车当前为空

Anti-IL10 Monoclonal Antibody

产品编号 TMAZ-0029
别名 Interleukin-10, Cytokine synthesis inhibitory factor

Anti-IL10 Monoclonal Antibody is a rabbit antibody targeting IL10. Anti-IL10 Monoclonal Antibody can be used in ELISA, FACS, IF.

Anti-IL10 Monoclonal Antibody

Anti-IL10 Monoclonal Antibody

纯度: 无数据
产品编号 TMAZ-0029 别名 Interleukin-10, Cytokine synthesis inhibitory factor

Anti-IL10 Monoclonal Antibody is a rabbit antibody targeting IL10. Anti-IL10 Monoclonal Antibody can be used in ELISA, FACS, IF.

规格价格库存数量
25 μg¥ 524.9¥ 9057日内发货
50 μg¥ 629.88¥ 1,0867日内发货
100 μg¥ 881.6¥ 1,5207日内发货
大包装 & 定制
加入购物车
实验操作小课堂
查看更多
联系我们获取更多批次信息
资源下载
TargetMol 的所有产品仅用作科学研究或药证申报,不能被用于人体,我们不向个人提供产品和服务。请您遵守承诺用途,不得违反法律法规规定用于任何其他用途。

产品介绍

生物活性
产品描述
Anti-IL10 Monoclonal Antibody is a rabbit antibody targeting IL10. Anti-IL10 Monoclonal Antibody can be used in ELISA, FACS, IF.
别名Interleukin-10, Cytokine synthesis inhibitory factor
Ig Type
Rabbit monoclonal IgG
交叉反应
Human
验证活性
Flow cytometry analysis of IL10 overexpressed 353F cells with TMAZ-0029, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line).
应用
ELISA, FACS, IF
推荐剂量
0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Single-pass type I membrane
构建方式This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of IL10 protein.
纯化方式Protein A Affinity Purified
性状Liquid
缓冲液0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin.
纯度> 95% as determined by SDS-PAGE.
研究背景Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3 (PubMed: 16982608). In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators (PubMed: 18025162). Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha (PubMed: 11564774, PubMed: 1940799, PubMed: 7512027). Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (PubMed: 8144879). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity)
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Biotin/APC/PE/AF488/AF555/AF647
可提供抗体种类
1
抗原信息
免疫原
IL10
抗原种属
Human
基因ID
3586
Uniprot ID
研究领域
Immunology Research
化学信息
分子量150 kDa
存储&运输
储存方式For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze.
运输方式For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice.

计算器

  • 稀释 计算器
Related Tags: buy Anti-IL10 Monoclonal Antibody | purchase Anti-IL10 Monoclonal Antibody | Anti-IL10 Monoclonal Antibody cost | order Anti-IL10 Monoclonal Antibody | Anti-IL10 Monoclonal Antibody molecular weight